Products for the prevention of metabolic diseases


Rumen protected and plain niacin products (70%) for ruminants

The physiological importance of niacin in animal organisms has been a well-known fact for a long time. Niacin is a constituent of two coenzymes, the nicotinamide-adenine-dinucleotide (NAD) and the nicotinamide-adenine-dinucleotide-phosphate (NADP). These coenzymes – connected to enzyme-proteins – transport the electrons in the synthesis and degradation of proteins, fats and carbo-hydrates, therefore they play an important role in the metabolism of the mentioned nutrients. There are just a few data mentioned in literature about the niacin-content of the feed to be utilized, thus it is difficult to determine exactly the niacin-supply of the ruminants.

Therefore, in practice the feed-portion of the animals is supplemented with niacin, especially in the periods of intensive metabolism (e.g.: in case of dairy cows, the first phase of lactation, weaning, starting the feed fattening, etc.). During the use of niacin, the safety of production increases, the possibility of energy-retention problems reduces. The niacin-content of the used forage significantly influences the niacin-synthesis of rumen-microbes, thus it is advised to dose a certain part of niacin supplemental in a rumen-protected form, which cannot or just to a limited extent can degrade bythe microbes.

The rumen-protected niacin products of Adexgo Ltd. are decisively utilized in the small intestine, which means a direct niacin-source in the crucial period of production. According to the experiments the rumen-protected niacin has a positive effect on N-metabolism as well.

The proportion utilized in the rumen has a positive effect on the operation of rumen-microbes. In case of plain niacin supplement, the propionic acid-concentration of rumen fluid increases, which – as a glucogenetic material – improves the glucose supply of ruminants, and it improves the effectiveness of lactose synthesis. The increasing propionic acid proportion improves the animals’ energy-balance; it also decreases the methane production in the rumen. Furthermore the niacin-supplement reduces the lactic acid concentration of the rumen fluid and it increases the pH-value of the rumen fluid.

According to the literature, niacin feeding – which is utilized both in the rumen and in the small intestine – has positive effect on rumen fermentation, on prevention of metabolic diseases (e.g.: acidosis, ketosis) and on N-metabolism and these positive effects occur simultaneously.

the role of niacin in preventing and in treating ketosis

Ketosis is a metabolic disease, in which the quantity of ketone-bodies (acetoacetate, β-hydroxybutyrate, acetone) and the free fatty acids increase in the blood-plasma, while the glucose-concentration decreases. According to some surveys more than 50% of the high yielding dairy cows suffer from sub-clinical ketosis. In case of ketosis the appetite, the feed-intake, the live weight and the milk production of the animals decrease.

Around the period of calving, in case of feeding 6-12 g niacin daily and per animal, the glucose concentration of the blood-plasma increases, the proportion of ketone-bodies and free fatty acids decreases while the milk production also increases. The favourable effects can be traced back to the antilipolytic effect of niacin on adipose tissues (for example: it intensifies glucose transport to the liver cells through diffusion; it reduces the c-AMP-content of adipose and other tissues; it lessens the butyrin concentration in the rumen, etc.).

advantages of feeding plain and rumen-protected niacin

  • feed-intake of ruminants improves
  • the quantity of ketone-materials in blood and the concentration of free fatty acids decrease
  • milk production increases
  • fat- and protein content of milk increases
  • as a result of the niacin utilized in the rumen the activity of rumen-microbes improves and the microbial-protein synthesis increases

suggested dose

9-17 g/cow/day (NIA-GO-70)
(feeding is suggested especially in the first phase of lactation)

The products can be used effectively in the feeding of dairy sheep and goat.

Related products


Rumen protected choline for ruminating animals

read more »


For animals rumen protected methionine

read more »


For animals rumen protected methionine and choline

read more »


Rumen-protected glucose product for dairy ruminating animals

read more »


Retard rumen-buffer-product for ruminating animals

read more »